Ngo-1500 BC, owokuqalai-capsulewazalelwa eGibhithe.
Ngo-1730, osokhemisi eVienna baqala ukwenzaamaphilisikusukela isitashi.
Ngo-1834,i-capsuleubuchwepheshe bokukhiqiza banelungelo lobunikazi e-Paris.
Ngo-1846, izingxenye ezimbili ezinzimai-capsuleubuchwepheshe bokukhiqiza batholwa e-France Patents.
Ngo-1848, izingcezu ezimbiliamaphilisiwaphuma.Kusukela lapho,Angenalutho amagobolondo e-capsule eqinilewangena emhlabeni wezokwelapha futhi waba iziqukathi zokupakisha zokwelapha.
Ngo-1874, ukukhiqizwa kwezimboni kanzimaamaphilisi(I-Hubel) yaqalwa eDetroit, futhi amamodeli ahlukahlukene aqalwa ngasikhathi sinye.
Ngo-1888, uParke-Davis wathola ilungelo lobunikazi lokukhiqizaama-capsules aqinileeDetroit (JB Russell)
Ngo-1931, uParke-Davis '.i-capsuleisivinini sokukhiqiza sifinyelele ku-10,000amaphilisingehora (A. Colton)
Njengento efanelekile yokupakisha yokwelapha,Angenalutho amagobolondo e-capsule eqinileasetshenziswa kabanzi emalungiselelweni emithi.Zisatshalaliswa ngokuyinhloko ku-powder, uketshezi, i-semi-solid, amafutha, amaphilisi kanye namanye amalungiselelo.Zingabola ngokushesha, ezinokwethenjelwa futhi ngokuphepha.Zinezinzuzo ezilandelayo:
1) Ukukhanya okuhle futhi kulula ukugwinya.
2) Umphumela wokufihla: Kungavala ukubaba okungakhululekile nephunga lomuthi, futhi kuvikele futhi kuzinzise okuqukethwe okungazinzile.
3) I-bioavailability ephezulu yomuthi:Amaphilisiakudingi ukunamathela nokucindezela ngesikhathi sokulungiselela njengamaphilisi namaphilisi, ngakho-ke ahlakazeka ngokushesha futhi amunce kahle esiswini nasemathunjini.
I-4) Ukuvikelwa okungcono kwemikhiqizo yamakhambi: Ngaphandle kokushisa okuphezulu nokucindezela okuphezulu okulethwa umshini wokucindezela ithebhulethi, isimo semvelo sezinto zokwelapha zesitshaloi-capsuleingagcinwa.
5) Ingenziwa ibe amalungiselelo okukhululwa okuqhubekayo kanye namalungiselelo ayinhlanganisela:
Umuthi ungakhululwa ngesikhathi nendawo (i-enteric-coated, pulsed kanye nezinye izinhlelo zokukhulula izidakamizwa).Uma isidakamizwa senziwa kuqala sibe yizinhlayiya, bese kusetshenziswa izinto zokusetshenziswa ze-gelatin nezinto ezisetshenziswayo ezinamanani ahlukene okukhululwa, umphumela wokukhipha isikhathi nokubeka indawo ungafinyelelwa.Ngakho-ke,amaphilisiamafomu emithamo afanelekile okuthuthukiswa kwamalungiselelo okukhululwa okuqhubekayo kanye namalungiselelo ayinhlanganisela.
6) Inqubo kadokotela kanye nokulungiselela ilula, ilungele ukwenziwa kwezimboni kanye ne-automation Production.
Isikhathi sokuthumela: Aug-24-2021