Ukwethulwa kohlobo lwe-II Collagen

Iyini i-collagen yohlobo lwe-II?

I-collagen yohlobo lwe-II iyiphrotheni ye-fibrillar eyakhiwe ngamaketanga amade angu-3 ama-amino acid akha inethiwekhi egcwele ngokuqinile yama-fibrils nemicu. Iyingxenye eyinhloko ye-cartilage emzimbeni. Iqukethe isisindo esomile nama-collagens.

I-collagen yohlobo lwe-II yilo olunikeza uqwanga amandla alo aqinile nokunwebeka, ngaleyo ndlela lukwazi ukusekela amalunga. Kuyasiza enqubweni yokubopha ngosizo lwe-fibronectin namanye ama-collagen.

Uyini umehluko phakathi kohlobo II kanye nohlobo lwe-collagen I?

Phezulu zibonakala zifana, ngayinye iyi-helix emithathu okungukuthi eyakhiwe ngamaketanga amathathu amade ama-amino acid. Nokho, ezingeni lamangqamuzana kunomehluko obalulekile.

Thayipha i-collagen: Amaketango amabili kwamathathu ayefana.

Uhlobo II collagen: Womathathu amaketanga ayefana.

I-Collagen yohlobo I itholakala kakhulu emathanjeni nasesikhunjeni. I-collagen yohlobo lwe-II itholakala kuphela ku-cartilage.

Yiziphi izinzuzo ezidlalwa uhlobo lwe-collagen lwe-II emzimbeni?

Njengoba sibonile, uhlobo lwe-II collagen luyingxenye enkulu yezicubu ze-cartilage. Ngakho ukuze uyiqonde ngempela indima eyidlalayo, umuntu kumelwe abheke umsebenzi woqwanga emzimbeni.

I-cartilage iyizicubu ezixhumene eziqinile kodwa ezithambile. Kunezinhlobo ezahlukene ze-cartilage emzimbeni, ngayinye inomsebenzi othize. I-cartilage etholakala emalungeni inemisebenzi eminingana, njenge

- ukuxhuma amathambo

- ukuvumela izicubu ukuthi zithwale ukucindezeleka komshini

- ukumuncwa ukushaqeka

- ukuvumela amathambo axhunyiwe ukuthi ahambe ngaphandle kokungqubuzana

Uqwanga lwakhiwe ama-chondrocyte okungamangqamuzana akhethekile adala lokho okwaziwa ngokuthi 'i-extracellular matrix' ehlanganisa i-proteoglycan, imicu ye-elastin kanye nohlobo lwe-II collagen fibers.

Uhlobo lwe-II lwemicu ye-collagen luyinto eyinhloko ye-collagenous etholakala ku-cartilage. Badlala indima ebaluleke kakhulu. Bakha inethiwekhi yama-fibrils esiza ukuhlanganisa i-proteoglycan ne-elastin fibers ibe izicubu eziqinile, kodwa eziguquguqukayo.