Izinhlobo ezihlukene ze-Collagen nokuthi Zisetshenziswa Kanjani
Emizimbeni yabantu, i-collagen ibaluleke njengenhliziyo emizimbeni yethu. Kusisiza ukuthi sihlale sibasha futhi sinempilo. Lapho sizalwa, i-collagen isezingeni eliphezulu, kodwa njengoba sikhula, ukuntuleka kwe-collagen kwenzeka, futhi siyakhula. Kodwa-ke, ukuguga kungancishiswa ngokuthatha izithako ze-collagen. Kodwa inkinga lapha ukuthi kunezinhlobo ezingama-28 ze-Collagen emizimbeni yethu, futhi kubaluleke kakhulu ukuqonda ukuthi yiluphi uhlobo lwe-Collagen olwenza ukuthi singasebenzisi ngokweqile kolunye uhlobo. Ngakho-ke, qhubeka uzigcine usemusha futhi unempilo.
Umfanekiso-no-1-Izinhlobo-ze-Collagen
➔ Uhlu lokuhlola
1.Iyini i-Collagen?
2.Isebenza Kanjani I-Collagen Emzimbeni?
3.Izinhlobonhlobo ze-Collagen: Yiziphi Izinhlobo Ezihlukene?
1) Iyini i-Collagen?
Njengoba nje izinwele zethu zikhula ngokwemvelo, i-Collagen iyiphrotheni eyenziwa umzimba wethu njalo.
Umfanekiso ongu-2-what-is-collagen
Kuyamangaza ukuqaphela ukuthi emzimbeni womuntu, cishe i-30% yesilinganiso samaprotheni siphethwe yi-Collagen, futhi uma kuqhathaniswa nesisindo somzimba wonke, amaprotheni akha i-14 ~ 16%. I-Collagen ikhona yonke indawo, njengomoya eMhlabeni; isibonelo, ungayithola ezithweni, emathunjini, emathanjeni, esikhunjeni, nakuzo zonke ezinye izingxenye zomzimba womuntu.
2) I-Collagen yenzani emzimbeni?
Lokhu okulandelayo yizindima ze-Collagen emzimbeni wethu:
Umfanekiso we-3 Iyini indima ye-collagen emzimbeni.
✓ Esikhumbeni - igcina ithambile, inwebeka, iqinile, futhi ingenamibimbi.
✓ Ungqimba olungaphezulu ezithweni namathumbu - yenza ungqimba oluvikelayo
✓ Ngaphakathi emathanjeni - kuyasiza ekwakhekeni kwamathambo, kwenyusa ukuminyana, futhi kubambezele i-osteoporosis
✓ Kumajoyinti - asiza ekwakhekeni kwawo lapho esebenza njengamaphoyinti okunamathiselwe & izinto ezimunca ukushaqeka
✓ Izinzipho - I-Collagen yenza i-keratin, eyenza-ke izinzipho. Ngakho-ke, i-Collagen inesibopho sokukhula kwezinzipho kanye nempilo
✓ Izinwele - Iphrotheni eyinhloko, i-keratin, ezinweleni, ivela ku-amino acid ethile ye-Collagen, ngakho-ke, ngokuyisisekelo, i-Collagen yenza izinwele. Ngaphezu kwalokho, isendlalelo se-dermis, lapho izimpande zezinwele (izimpande) zikhona, zenziwe kakhulu nge-Collagen.
✓ Imithambo yegazi - Imicu ye-Collagen ikhona ngaphansi kongqimba lwangaphakathi lwemithambo yegazi ngendlela yenethiwekhi. Ngaphezu kwalokho, banikeza ukusekelwa kwesakhiwo, futhi ngesikhathi sokulimala, basebenza njengozibuthe wama-ejenti okwelapha futhi basize ukulungisa.
✓ Phakathi kwezintambo zemisipha - sebenza njengeglue yemisipha, igcine ihlangene futhi inikeze ukunwebeka kwezicubu. Ziphinde zisebenze njengendlela yokudlulisa amandla enkontileka ukusuka emisipha kuya kumathambo (amathambo, imisipha, imisipha).
3) Yiziphi izinhlobo ezahlukene ze-Collagen?
Umfanekiso ongu-4-Yiziphi-izinhlobo-ezihlukile-ze-Collagen
Ososayensi bathole izinhlobo ezingaphezu kuka-28 ze-Collagen futhi zihlukaniswa ngokusekelwe ezintweni zabo zokwakha, ukuhlelwa kwesakhiwo, nemisebenzi abayenzayo.
Kulezi zinhlobo ezingama-28, kukhona ama-Collagens angu-5 anomphumela omningi, njengokuthi;
a) Uhlobo lwe-Collagen I (luningi kakhulu)
b) Uhlobo lwe-Collagen II
c) Uhlobo lwe-Collagen III (luningi kakhulu)
d) Uhlobo lwe-Collagen V
e) Uhlobo lwe-Collagen X
a) Thayipha I-Collagen & Ukusetshenziswa kwayo
"Uhlobo lwe-Collagen luyiprotheni ende, ene-triple-helical, futhi lwenziwe ngama-amino acid amathathu: i-glycine, i-proline, ne-hydroxyproline. Izinsalela ze-glycine zakha umnyombo we-triple helix, kuyilapho izinsalela ze-proline ne-hydroxyproline zinikeza ukuguquguquka namandla."
Ungakwazi ukulinganisa ukubaluleka kwe-Type I Collagen kusukela endaweni yayo yokuqala esigabeni sokuqamba amagama ngoba iqukethe i-90% yawo wonke ama-Collagen emzimbeni womuntu, ikakhulukazi esikhumbeni, emathanjeni, nasezicubu ezixhumeneyo ( izintambo, imigqa, i-cartilage).
➔ Ukusetshenziswa Kohlobo I-Collagen
Njengoba Uhlobo I Collagen luningi esikhumbeni nasemathanjeni, ungalinganisa umsebenzi walo oyinhloko ukugcina isikhumba sisesisha nokugcina amandla amathambo - imininingwane enikezwe ngezansi;
✓ Impilo yesikhumba: Uma unemibimbi, ubuthuntu, noma ukuhwalala esikhunjeni sakho, khona-ke inkinga yaso enkulu ukuntuleka kohlobo lwe-Collagen I.
✓ Ukufinyela kwemisipha: Uhlobo I-Collagen nayo ibalulekile ekufinyezeni kwemisipha. Kuyasiza ukuxhuma imicu yemisipha futhi ivumela ukuthi ifinyeze futhi iphumule.
✓ Ukwakheka kwemithambo yegazi: Uhlobo lwe-Collagen I nalo lubalulekile ekwakhekeni kwemithambo yegazi. Kuyasiza ukwakha izindonga zemithambo yegazi futhi igcine iqinile futhi inempilo.
✓ Ukuphola kwesilonda: Uhlobo I I-Collagen nayo ibalulekile ekwelapheni kwesilonda. Kuyasiza ukwenza utwayi phezu kwesilonda futhi kunikeza uhlaka lokukhula kwezicubu ezintsha.
✓ Ukulungisa uqwanga: Amalunga emzimbeni womuntu enziwe ngento eyisivikelo ebizwa ngokuthi uqwanga, futhi lolu qwanga lwenziwe ngokuyinhloko ngoHlobo I-Collagen. Uqwanga lusebenza njengento edonsa ukushaqeka kanye nephuzu elinciphisa ukungqubuzana phakathi kwamathambo amabili.
✓ Ukwakheka Kwamathambo: Ngaphandle kwamathambo, sifana nendwangu ende elele phansi. Umzimba wethu ukhiqiza amathambo ikakhulukazi ngo-Type I collagen. Ngakho-ke, i-Type I Collagen eyengeziwe isho ukukhiqizwa okungcono kwamathambo, ukuphulukiswa okusheshayo, nokwakheka kwamathambo okuqinile.
b) Uhlobo II I-Collagen Nokusetshenziswa kwayo
"Uhlobo II lwe-Collagen lwakhiwe amaketanga amathathu amade ama-amino acid ahlanganiswe ndawonye ukuze akhe i-triple helix. I-triple helix inikeza uhlobo lwe-II amandla e-Collagen nokuguquguquka."
Ikhona ngobuningi ku-cartilage yelunga futhi inesibopho sokuletha ukuqina nokuguquguquka. Izithako ze-Collagen zohlobo lwe-II zivame ukwenziwa ngoqwanga lwenkukhu noma lwezinkomo.
➔ Ukusetshenziswa kohlobo lwe-II Collagen
✓ Impilo ehlangene: I-Type II Collagen igcwele kakhulu ku-cartilage, ngakho kunengqondo ukuthi ukuthatha izithasiselo zayo kuzosiza ekwelapheni izifo zamathambo namalunga njenge-osteoarthritis, njll. Iphinde isize ukukhululeka ebuhlungwini bamalunga futhi yengeze ukuqina emalungeni ukuze anyakaze kangcono.
✓ Impilo yesikhumba: Olunye ucwaningo lubonise ukuthi izithasiselo ze-Collagen zohlobo lwe-II zinganciphisa ukubukeka kwemibimbi namachashaza obudala futhi zisize ukuthuthukisa ukunwebeka kwesikhumba.
✓ Impilo yamathumbu: Ezinye izifundo zocwaningo zibonise ukuthi uhlobo lwe-II lwezithako ze-Collagen lungasiza ukuvikela indawo yangaphakathi/yangaphandle yamathumbu kanye nokwenza ngcono ukugayeka kokudla kanye nokumuncwa kwemisoco.
✓ Ukusebenza kwamasosha omzimba: Izithako ze-Collagen zohlobo lwe-II nazo ngezinye izikhathi zisetshenziselwa ukusiza amasosha omzimba ukulwa nezifo, okuholela ekululameni ngokushesha ezifweni.
c) Uhlobo III I-Collagen Nokusetshenziswa kwayo
“Ngokwesakhiwo, i-Type III Collagen yakheka ngamaketango e-alpha amathathu afanayo, okuyenza ibe i-homotrimer, ngokungafani noHlobo I-Collagen, enamaketanga amabili e-alpha1 kanye neketango elilodwa le-alpha2.”
Uma kukhulunywa ngo-Type III collagen, iyisigaba sesi-2 esitholakala ngobuningi be-Collagen emzimbeni womuntu. Kusatshalaliswa kabanzi kuzo zonke izicubu ezihlukene ezifana namathumbu, imithambo yegazi, isibeletho, isikhumba, nezitho zomzimba. Ngokusho kwedatha evela ezingxenyeni ezihlukahlukene zomzimba womuntu, kuqoshwa isilinganiso sohlobo lwe-Collagen I kuya ku-Type III ye-Collagen sifana no-4:1 ( isikhumba ), 3:1 ( izitho), njll.
Lolu hlobo lwe-Collagen, olubizwa ngokuthi i-fibrillar, ludala imicu emide, emincane enikeza izicubu amandla nokuguquguquka. Ngaphezu kwalokho, iphinde isize izilonda ziphole ngokushesha. Ukwengeza, igcina ukwakheka kwemithambo yegazi nezinye izitho, kusize ukusebenza kwazo ngendlela efanele.
➔ Ukusetshenziswa kohlobo lwe-II Collagen
✓ Impilo ehlangene: Uhlobo lwe-III I-Collagen ayiyona insada emathanjeni naku-cartilage, kodwa ikhona futhi isiza ukusekela ezinye izinhlobo ze-cartilage ukugcina amandla nempilo yamathambo.
✓ Impilo yesikhumba: I-Collagen yohlobo lwe-III igcwele kakhulu esikhumbeni, njengo-Type I Collagen, futhi isiza isikhumba ukuthi sigweme imigqa emihle, kamuva ephenduka imibimbi. Ngaphezu kwalokho, i-Type III Collagen yakha inethiwekhi yesakhiwo ngaphansi kwesikhumba ukuze igcine isikhumba siqinile, kodwa njengoba i-Collagen inwebeka, isikhumba sihlala sinwebeka.
✓ Impilo yezinwele: I-Tpye III Collagen ihlinzeka ngezinto ezingavuthiwe zokwakheka kwezinwele, ngakho-ke ithuthukisa ukukhula kwezinwele namandla. Ngaphezu kwalokho, amaprotheni ohlobo lwe-III nawo atholakala esikhunjeni lapho izimpande zezinwele zikhona. Ngamafuphi, ukuthatha izithasiselo ze-Collagen zohlobo lwe-III kuzosiza umuntu onezinwele ezibuthakathaka.
✓ Ukuphulukiswa kwesilonda: Uhlobo lwe-III luyiphrotheni yesibili ye-Collagen egcwele kakhulu emisipha nezitho, futhi njengoba wazi, i-Collagen iwuzibuthe wemvelo wamaseli okuphulukisa; uma kwenzeka noma yikuphi ukulimala, i-Collagen isiza ukwakha izicubu ezintsha ngokushesha.
✓ Ukungavikeleki: I-Collagen yohlobo lwe-III ingasiza ekuthuthukiseni ukuzivikela komzimba ngokuvusa ukukhiqizwa kwamaseli amhlophe egazi. Imvamisa isetshenziselwa izithasiselo zokwelapha izifo ze-autoimmune nezinye izifo zamasosha omzimba.
d) Thayipha i-Collagen ye-V kanye nokusetshenziswa kwayo
“Lolu hlobo lwe-Collagen luhlukaniswa njenge-fibrillar, luhlanganisa imicu emide, efana nekhebula enikeza amandla nokuvumelana nezimo ezicutshini - lusebenza ne-Type I kanye ne-Type III Collagens, idala isikafula sezicubu nezitho zomzimba.”
I-Collagen yohlobo lwe-V ayiningi njengezinye izinhlobo ezinhlanu ezinkulu ze-Collagen, kodwa yenza imisebenzi ebalulekile njengokwenza i-cornea yamehlo, izingqimba zesikhumba nezinwele, kanye nezicubu ze-placenta. Isebenza ngaphakathi kwe-matrix engaphandle kwezicubu ezihlukene, njengesikhumba, amathambo, imithambo yegazi kanye ne-placenta, inikeza ukusekelwa kwesakhiwo okubalulekile.
➔ Ukusetshenziswa kohlobo lwe-II Collagen
✓ Izinwele Nezinzipho: Isekela impilo nokuqina kwezinwele nezinzipho.
✓ Impilo Yamehlo: Iyingxenye ebalulekile ye-cornea, enomthelela ekugcineni isimo seso nokucaca.
✓ Ukuqina Kwesikhumba: I-Collagen yohlobo lwe-V isiza ekusimamiseni impilo yesikhumba, ibe nomthelela emandleni nasekunwebekeni kwaso.
✓ Imithambo yegazi: Uhlobo lwe-V I-Collagen yakha ukwakheka kwezindonga zemithambo yegazi, okunomthelela ekuzinzeni nasekusebenzeni kwayo ngendlela efanele.
✓ Ukwakheka Kwezicubu: I-collagen yohlobo lwe-V isiza ezinye izinhlobo ze-collagen ekukhiqizeni izicubu ezihlukahlukene nezendlalelo zesitho, ngakho isiza ekukhuleni kwazo okunempilo.
e) Thayipha X Collagen & Ukusetshenziswa kwayo
"Uhlobo lwe-X Collagen luhlanganisa i-helix emfushane kathathu ye-Collagen ezungezwe izizinda ezimbili ezingezona i-collagenous, i-NC2 ne-NC1."
Kuyasiza ekubopheni amaminerali abalulekile, njenge-calcium, emiculweni ye-Collagen, kuthuthukise amandla amathambo - ngokwenza kanjalo, kunomthelela ekuqineni kwesistimu yethu yamathambo.
Ngokungafani nezinye izinhlobo ze-Collagen, ayidali imicu emide kodwa yakha inethiwekhi yemicu emifushane. Le nethiwekhi ehlukile inikeza amandla kanye nokuguquguquka kwepuleti lokukhula kanye nendawo ebaliwe ye-articular cartilage.
➔ Ukusetshenziswa kohlobo lwe-II Collagen
Okulandelayo okunye ukusetshenziswa kohlobo X Collagen;
✓ Indima Ekhethekile: Noma itholakala ngamanani amancane, ukusebenza kwayo okuhlukile ekuthuthukisweni kwamathambo kugqamisa ukubaluleka kwayo.
✓ I-Transition Signifier: Uhlobo X I-Collagen isebenza njengomaka phakathi nokuthuthukiswa kwamathambo, okubonisa ukusuka ku-cartilage kuya ethanjeni eliqinile.
✓ Inkomba Yeplate Lokukhula: Ukuba khona kwayo kumapuleti okukhula kubonisa uguquko olubalulekile olusekela ukukhula kwethambo longitudinal.
✓ Umgqugquzeli Wokukhula: Ngokusiza lolu shintsho, i-Type X Collagen iqinisekisa ukuthi amathambo akhula ngobude nangamandla, okubalulekile empilweni eqinile yamathambo kanye nobuqotho besakhiwo.
➔ Isiphetho
Abakhiqizi be-collagen emhlabeni jikelele benza izithasiselo ezikhethekile ezigxile ekukhiqizeni uhlobo oluthile lwe-Collagen, njengoHlobo I noma Uhlobo II nezinye. Kodwa-ke, kubalulekile ukuqaphela ukuthi abanye bangabakhiqizi be-Collagen bezinkomo, abanye bayingulube, kanti abanye basebenzisa izingxenye zezilwane ezixubile - okungaba yinkinga ngekhwalithi nakwamanye amasiko ( ingulube i-Collagen i-haram in Islam).
Kodwa-ke, thina kwa-Yasin sihlose ukwenza i-Collagen kuzo zonke izinhlobo zezilwane kodwa ezitsheni ezithile ukuqinisekisa ukuthi abathengi bathola lokho abakufunayo. Ngakho-ke, uma ungowabahlinzeki bamaprotheni noma abahlinzeki bempushana ye-Collagen, singaqinisekisa ukuthi uthola imikhiqizo eyiqiniso engu-100% kithi.