Izici ze-inkukhu collagen

I-Chicken Collagen iyiphrotheni enkulu ye-extracellular matrix. Njengoba kunikezwe amaphrofayili anamandla okulwa nokuvuvukala kanye ne-antioxidant alezi zinhlanganisela ze-bioactive, kube nesithakazelo esikhulayo ekusebenziseni ama-peptide atholakala ku-collagen kanye nama-collagen hydrolysates acebile nge-peptide empilweni yesikhumba, ngenxa yemiphumela yawo yokuzivikela, i-antioxidant kanye ne-proliferative ku-dermal fibroblasts. Kodwa-ke, wonke ama-hydrolysates awasebenzi ngokulinganayo ekusebenziseni imiphumela enenzuzo; ngakho-ke, ucwaningo olwengeziwe luyadingeka ukuze kutholwe izici ezithuthukisa ukusebenza kokwelapha kwamalungiselelo anjalo. Sisebenzise izimo ezihlukene ze-enzymatic ukuze sikhiqize inani lama-collagen hydrolysates ahlukene anamaphrofayili e-peptide ahlukile. Sithole ukuthi ukusetshenziswa kwe-enzyme emibili kuneyodwa ye-hydrolysis kukhiqiza inala enkulu yama-peptide esisindo samangqamuzana aphansi ngokuthuthukiswa okulandelanayo kwezakhiwo ze-bioactive. Ukuhlola lawa ma-hydrolysates ku-human dermal fibroblasts kubonise izenzo ezihlukile ezinguqukweni zokuvuvukala, ukucindezeleka kwe-oxidative, uhlobo lwe-collagen synthesis lwe-I kanye nokwanda kwamaselula. Okutholakele kwethu kusikisela ukuthi izimo ezihlukene ze-enzymatic zithinta iphrofayili ye-peptide yama-hydrolysates futhi zilawula ngokuhlukile imisebenzi yazo yebhayoloji kanye nezimpendulo ezingaba zokuvikela ku-dermal fibroblasts.

Umthamo ofanelekile wohlobo lwe-collagen II uncike ezintweni ezimbalwa ezifana neminyaka yomsebenzisi, impilo, nezinye izimo ezimbalwa. I-Chicken collagen iqukethe namakhemikhali e-chondroitin ne-glucosamine, angasiza ekwakheni kabusha uqwanga.