Izinzuzo zeCapsule

Ngo-1500 BC, i-capsule yokuqala yazalwa eGibhithe.

Ngo-1730, osokhemisi eVienna baqala ukwenza amaphilisi ngesitashi.

Ngo-1834, ubuchwepheshe bokukhiqiza ama-capsule banelungelo lobunikazi eParis.

Ngo-1846, ubuchwepheshe bokukhiqiza ama-capsule obunzima obunezigaba ezimbili batholwa e-France Patents.

Ngo-1848, ama-capsules aneziqephu ezimbili aphuma. Kusukela lapho, amagobolondo ama-capsule aqinile angenalutho angena emhlabeni wezokwelapha futhi aba iziqukathi zokupakisha zokwelapha.

Ngo-1874, ukukhiqizwa kwezimboni zama-capsules aqinile (Hubel) kwaqalwa eDetroit, futhi amamodeli ahlukahlukene aqalwa ngasikhathi sinye.

Ngo-1888, uParke-Davis wathola ilungelo lobunikazi lokukhiqiza amaphilisi aqinile eDetroit (JB Russell)

Ngo-1931, ijubane lokukhiqiza i-capsule likaParke-Davis lafinyelela ku-10,000 capsules ngehora (A. Colton)

Njengento efanelekile yokupakisha yokwelapha, amagobolondo e-capsule eqinile angenalutho asetshenziswa kabanzi ekulungiseleleni imithi. Zisatshalaliswa ngokuyinhloko ku-powder, uketshezi, i-semi-solid, amafutha, amaphilisi kanye namanye amalungiselelo. Zingabola ngokushesha, ezinokwethenjelwa futhi ngokuphepha. Zinezinzuzo ezilandelayo:

1) Ukukhanya okuhle futhi kulula ukugwinya.

2) Umphumela wokufihla: Kungavala ukubaba okungakhululekile nephunga lomuthi, futhi kuvikele futhi kuzinzise okuqukethwe okungazinzile.

I-3) I-bioavailability ephezulu yomuthi: Amaphilisi awadingi ukunamathela nokucindezela ngesikhathi sokulungiselela njengamaphilisi namaphilisi, ngakho ahlakazeka ngokushesha futhi amunce kahle esiswini nasemathunjini.

I-4) Ukuvikelwa okungcono kwemikhiqizo ye-herbal: Ngaphandle kokushisa okuphezulu nokucindezela okuphezulu okulethwa umshini wokucindezela ithebhulethi, isimo semvelo sezinto zokwelapha zesitshalo ku-capsule singagcinwa.

5) Ingenziwa ibe amalungiselelo okukhululwa okuqhubekayo kanye namalungiselelo ayinhlanganisela:

Umuthi ungakhululwa ngesikhathi nendawo (i-enteric-coated, pulsed kanye nezinye izinhlelo zokukhulula izidakamizwa). Uma isidakamizwa senziwa kuqala sibe yizinhlayiya, bese kusetshenziswa izinto zokusetshenziswa ze-gelatin nezinto ezisetshenziswayo ezinamanani ahlukene okukhululwa, umphumela wokukhipha isikhathi nokubeka indawo ungafinyelelwa. Ngakho-ke, ama-capsules angamafomu afanelekile womthamo wokuthuthukiswa kwamalungiselelo okukhululwa okuqhubekayo kanye namalungiselelo ahlanganisiwe.

6) Inqubo kadokotela kanye nokulungiselela ilula, ilungele ukwenziwa kwezimboni kanye ne-automation Production.